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This clinical epidemiological study will determine if farm workers chronically exposed to organophosphate pesticides (OP) in field work have quantifiable nervous system abnormalities after an exposure season and whether these changes are persistent after a several month period of non-exposure. This cross-sectional study with a follow-up component will compare 50 female orchard farmworkers with chronic low-level OP exposure to controls. Exposure estimates will be based on orchard spray logs, work questionnaires, and biological monitoring (cholinesterase testing). A neurological battery will be used at the end of an exposure season and 5-6 months after no exposure. Several biological markers will be evaluated: cholinesterase, paraoxonase, chlorpyrifos oxonase levels, and muscarinic receptor density in lymphocytes. Assessment of Occupational Exposure To Aflatoxin Researcher: Mustafa I. Selim, Ph.D. Affiliation: University of Iowa College of Medicine Department of Preventive Medicine & Environmental Health 137 AMRF Oakdale Campus Iowa City, Iowa 52242

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تاریخ انتشار 1997